A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor
Identifieur interne : 001B14 ( Main/Exploration ); précédent : 001B13; suivant : 001B15A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor
Auteurs : I. Milanov [Bulgarie]Source :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 2000.
English descriptors
Abstract
Background: Whether dopaminergic and anticholinergic drugs exert influence on parkinsonian rest and postural tremor is a subject of debate. Different types of tremor may be influenced differently by the drugs. The aim of this study was to reevaluate the differential effects of levodopa and anticholinergic drugs on parkinsonian tremor in different limb positions and on different types of postural tremor. Methods: Thirty-eight patients with parkinsonian resting tremor and postural tremor were included in this study. Patients were divided into two groups according to the electromyographic pattern of the postural tremor. We found fast synchronous postural tremor (>7Hz) in 16 patients, and slow alternating postural tremor in 22 patients. The tremor was scored clinically in each limb position using the Webster Tremor Scale. Surface electromyographic recordings from the most involved limb in all positions were also performed. The patients were randomly assigned to levodopa (one 250/50-mg tablet), or to biperiden (one 3-mg tablet). Tremor was assessed by clinical and electromyographic examinations at base line 1h following ingestion of the drug. The subjective tremor improvement was also assessed. Results: We found that levodopa had a good effect on the amplitude of the resting tremor, while the effect of biperiden was weaker. Both levodopa and biperiden has less effect on postural tremor. However, levodopa's effect was better than that of biperiden. Levodopa and biperiden had better effect on slow alternating postural tremor than on fast synchronous postural tremor. They had no effect on kinetic and intention tremors. Conclusions: Levodopa and anticholinergic drugs have differing effects on both resting and postural tremor Also, the different categories of postural tremor respond differently to treatment. The mechanisms underlying resting parkinsonian tremor may be different from those underlying postural, kinetic and intention tremor. Moreover, the mechanisms underlying different types of postural tremor may be different.
Url:
DOI: 10.1016/S1353-8020(00)00077-8
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor</title><author><name sortKey="Milanov, I" sort="Milanov, I" uniqKey="Milanov I" first="I." last="Milanov">I. Milanov</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B563E5C24EC5203DD8B15D15B201DD83C1B9C78E</idno><date when="2001" year="2001">2001</date><idno type="doi">10.1016/S1353-8020(00)00077-8</idno><idno type="url">https://api.istex.fr/document/B563E5C24EC5203DD8B15D15B201DD83C1B9C78E/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001468</idno><idno type="wicri:Area/Main/Curation">001248</idno><idno type="wicri:Area/Main/Exploration">001B14</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor</title><author><name sortKey="Milanov, I" sort="Milanov, I" uniqKey="Milanov I" first="I." last="Milanov">I. Milanov</name><affiliation wicri:level="1"><country xml:lang="fr">Bulgarie</country><wicri:regionArea>University Neurological Hospital, ”St. Naum“ III Neurological Clinic, Blvd. Tzarigradsko shosse-IV km, 1113 Sofia</wicri:regionArea><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation><affiliation><wicri:noCountry code="no comma">E-mail: milanovivan@hotmail.com</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Parkinsonism and Related Disorders</title><title level="j" type="abbrev">PRD</title><idno type="ISSN">1353-8020</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">8</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="67">67</biblScope><biblScope unit="page" to="73">73</biblScope></imprint><idno type="ISSN">1353-8020</idno></series><idno type="istex">B563E5C24EC5203DD8B15D15B201DD83C1B9C78E</idno><idno type="DOI">10.1016/S1353-8020(00)00077-8</idno><idno type="PII">S1353-8020(00)00077-8</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1353-8020</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Electromyography</term><term>Parkinson's disease</term><term>Treatment assessment</term><term>Tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Whether dopaminergic and anticholinergic drugs exert influence on parkinsonian rest and postural tremor is a subject of debate. Different types of tremor may be influenced differently by the drugs. The aim of this study was to reevaluate the differential effects of levodopa and anticholinergic drugs on parkinsonian tremor in different limb positions and on different types of postural tremor. Methods: Thirty-eight patients with parkinsonian resting tremor and postural tremor were included in this study. Patients were divided into two groups according to the electromyographic pattern of the postural tremor. We found fast synchronous postural tremor (>7Hz) in 16 patients, and slow alternating postural tremor in 22 patients. The tremor was scored clinically in each limb position using the Webster Tremor Scale. Surface electromyographic recordings from the most involved limb in all positions were also performed. The patients were randomly assigned to levodopa (one 250/50-mg tablet), or to biperiden (one 3-mg tablet). Tremor was assessed by clinical and electromyographic examinations at base line 1h following ingestion of the drug. The subjective tremor improvement was also assessed. Results: We found that levodopa had a good effect on the amplitude of the resting tremor, while the effect of biperiden was weaker. Both levodopa and biperiden has less effect on postural tremor. However, levodopa's effect was better than that of biperiden. Levodopa and biperiden had better effect on slow alternating postural tremor than on fast synchronous postural tremor. They had no effect on kinetic and intention tremors. Conclusions: Levodopa and anticholinergic drugs have differing effects on both resting and postural tremor Also, the different categories of postural tremor respond differently to treatment. The mechanisms underlying resting parkinsonian tremor may be different from those underlying postural, kinetic and intention tremor. Moreover, the mechanisms underlying different types of postural tremor may be different.</div></front></TEI><affiliations><list><country><li>Bulgarie</li></country><region><li>Sofia-ville (oblast)</li></region><settlement><li>Sofia</li></settlement></list><tree><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Milanov, I" sort="Milanov, I" uniqKey="Milanov I" first="I." last="Milanov">I. Milanov</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B14 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B14 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B563E5C24EC5203DD8B15D15B201DD83C1B9C78E
|texte= A cross-over clinical and electromyographic assessment of treatment for parkinsonian tremor
}}
| This area was generated with Dilib version V0.6.23. |  |